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Didanosine (ddI)
Didanosine, commonly known as ddI (2',3'-dideoxyinosine), is an antiretroviral medication used in the treatment of HIV/AIDS. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs) and works by interfering with viral replication through mimicking natural cellular nucleosides. Didanosine is a white solid with the chemical formula C10H12N4O3.
Key Details:
Name: Didanosine (ddI)
Chemical Formula: C10H12N4O3
Description:
Appearance: White crystalline powder.
Mechanism: A purine nucleoside analogue that is converted intracellularly
to dideoxyadenosine triphosphate (ddATP). This active metabolite inhibits HIV
reverse transcriptase by acting as a chain terminator, thereby preventing the
synthesis of viral DNA.
Uses:
- Medical Treatment: Used in combination with other antiretroviral drugs to manage HIV-1 infection.
- Clinical Application: Prescribed as a therapeutic agent for patients with AIDS or individuals who are HIV-positive.
Note: In some industrial contexts, the abbreviation DDI may refer to Dimeryl Diisocyanate. However, in pharmacology and clinical medicine, ddI almost exclusively refers to the antiviral drug Didanosine.
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